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To further determine the biological functions of this system, multi-dimensional experimental validation was conducted using cells, in vitro experiments, and in vivo evaluations on mice

Apremilast, a newer oral drug, is a phosphodiesterase 4 (PDE4) inhibitor that regulates inflammation by reducing the production of pro-inflammatory cytokines (Perez-Aso et al

For example, negatively charged nanoparticles interact selectively with neuronal membranes in comparison with positively charged or uncharged ones (85)

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Moreno-Snchez R, Bravo C, Vsquez C, Ayala G, Silveira LH, Martnez-Lavn M (1999) Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: study in mitochondria, submitochondrial particles, cells, and whole heart