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This novel signaling pathway defines a mechanism by which the metabolic state of a cell can affect its epigenome, and thus gene expression in a potentially stable and heritable manner, in response to the cellular environment (Wu et al., 2018[160]) (Figure 4(Fig

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doi: 10.3389/fimmu.2023.1059956 Received 02 October 2022 Accepted 27 January 2023 Published 09 February 2023 Volume 14 - 2023 Edited by Carla Maris Machado Bittar, Luiz de Queiroz College of Agriculture, University of So Paulo, Brazil Reviewed by Viviani Gomes, Faculty of Veterinary Medicine and Animal Science, University of So Paulo, Brazil

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