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Moreover, apathy in AD patients may limit physical exercise, a potent activator for increasing peripheral BDNF (Ribeiro et al., 2021)

When Wnt ligands bind to Frizzled receptors on the cell surface, they activate a protein called Dishevelled

Vegetarians and vegans are particularly at risk, as B12 is primarily found in animal-based foods

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In liver and adipose, gene signatures reflecting enhanced oxidative metabolism and reduced lipogenesis/lipid storage add mechanistic depth