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For instance, the expression of ChR2 in Purkinje cells, which can be induced using transgenic mutant mice, by in utero electroporation or by viral injections [107], allows precise control over action potential firing in their downstream target, the cerebellar nuclei [108] and thereby over cerebellar-evoked excitation or inhibition in the thalamus

An oversupply with cobalamin is also possible, for which there are pathological causes, for example

Fraenkel et al., 2021)