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Thompson et al., 1993

Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22-CCR4-ATF6-GRP78 axis

[] Heavy metals, mainly lead, may also substitute bivalent cations such as calcium ion (Ca2+), magnesium ion (Mg2+), iron (II) (Fe 2 +) and monovalent cations such as sodium ion (Na+) and cause dysfunctions where these cations act as cofactors in various enzyme activities