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When determining the Alanine to Lysine ratio as an indirect measure of mitochondrial distress we found that unaffected children had an average ratio of 5.8 and those with konzo have an average ratio of 6.9, both of which are substantially higher than the expected ratio of less than 3 for healthy adolescents (Fig

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The role of increased intestinal permeability in disease progression was reinforced when reduced levels of T1D development were recorded in rodent models fed gluten-free diets (Visser et al