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10.1021/acsami.7b05142 258 ZhangJ

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166 MiR-126 also downregulates the target gene Sprouty-related protein 1 (SPRED1) which then activates the Raf-1/ERK1/2 signaling contributing to angiogenesis

Additional testing parameters: These validation methods minimize variables and contamination risks that could affect experimental results

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Reassuringly, genes that are upregulated in HLRCC clinical samples relative to normal kidney tissues 7 are also significantly enriched with oxidative stress genes (hypergeometric P value of 3.984e06)