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In addition to its benefits in inhibiting tumor growth, ACSL4-dependent ferroptosis is implicated in radiation-induced intestinal injury, a common gastrointestinal complication resulting from radiotherapy [185]

4-HNE can activate various molecules, such as NF- B and NOX4, to induce RPE apoptosis, lysosomal imbalance, and lipofuscin production, resulting in photoreceptor cell destruction and consequently, age-related visual impairment such as AMD

Additionally, in a study of patients who underwent bariatric surgery, CK-18 levels were found to indicate continued liver damage after surgery [223]

Giles FJ, Faderl S, Thomas DA, Cortes J, Jeha SS, Garcia-Manero G, Douer D, Levine AM, Estey EH, Beran M, OBrien S, Koller C, Andreeff M , H: K

Emerging evidence highlights the role of trimethylamine N-oxide (TMAO) in regulating bile acid metabolism and liver regeneration

Tirzepatide does not typically disrupt sleep, though some researchers report tirzepatide-related sleep changes that may need management