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Summary Keywords ferroptosis, angiogenesis, metabolic reprogramming, extracellular vesicles, oxidative stress, tumor microenvironment Citation Tatode A, Chaudhary AA, Qutub M, Trivedi R, Umekar M, Ali MAM and Premchandani T (2025) Dissecting the opposing regulatory functions of endogenous nitric oxide production in colorectal cancer initiation, adaptive immune response alterations, and ferroptosis execution

The lactate accumulation from aerobic glycolysis acidifies the TME and promotes the M2 tumor-associated macrophage (TAM) polarization of these macrophages and microglial cells

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The lower levels of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins observed in mice lacking SCAP highlight the critical role of cholesterol in mediating vesicle fusion with the presynaptic membrane (van Deijk et al., 2017)