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In the vulnerable fetal and infant CNS, detoxification capacity is limited

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Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA

This must tax regulatory systems that prevent abnormal redox cycling of iron, such as the Fe 2+ -glutathione complexes considered the dominant form of iron in the cellular labile iron pool 22

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Promoting extracellular matrix remodeling via ascorbic acid enhances the survival of primary ovarian follicles encapsulated in alginate hydrogels