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The administered doses for the mouse experiments were set at 12 and 48 times (7.2 mg/d and 28.8 mg/d) the adult intake dose (assuming an adult body weight of 60 kg and a conversion factor of 12.33), according to the calculated method of Huang et al

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Targeted Supplementation Evidence-based supplements may include: Vitamin D3 for immune and hormonal regulation Selenium and zinc for thyroid antibody reduction and hormone conversion Iron (when deficient) to aid thyroid hormone production Glutathione and antioxidants for detox support and immune modulation Adaptogens like ashwagandha and rhodiola to regulate stress response 4

The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM

*Correspondence: Aldona Baltusnikiene, [email protected] This article was submitted to Renal Physiology and Pathophysiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

However, normal levels of uric acid provide antioxidant function