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Acknowledgements This work was supported by the Joint project of Chongqing Municipal Science and Technology Bureau and Chongqing Health Commission (2023CCXM003), the Natural Science Foundation Project of China (82371526), the Natural Science Foundation of Chongqing (CSTB2024NSCQ-QCXMX0033 and CSTB2024NSCQ-MSX1027), the Young Elite Scientists Sponsorship Program by CAST (2021QNRC001), and the Chongqing Medical Science and Technology Innovation Four Centers Construction Project - Chongqing Clinical Evaluation and Research Center for Cardiovascular and Cerebrovascular Drug and Devices (Materials) Project

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James OBrien, the condition may indicate an underlying life-threatening disease such as congestive heart failure, or it may be caused by something as benign as sitting for too long (OBrien 2005)

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