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Vzquez et al., 2015a

This process can be activated by cellular changes, including DNA damage, mitochondrial damage, withdrawal of growth factors and estrogen signaling [17, 37]

Another unique feature is that the body produces glutathione inside cells, where it helps protect DNA, proteins, cell membranes, and mitochondria from oxidative damage

Consequently, the development of safe and effective lipid-lowering agents has a high social and economic implications and has emerged as a focal point of research worldwide

Animal experiments have confirmed that PHGDH knockdown or treatment with its specific inhibitors effectively suppresses the growth of AML xenografts without significant toxicity to normal hematopoietic stem cells (95)

doi: 10.1080/19490976.2020.1732268 176 LanzaMFilipponeAArdizzoneACasiliGPaternitiIEspositoEet al