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Although there is still controversy regarding the impact of HCA on liver and kidney injuries, our findings did not reveal any evidence of increased hepatotoxicity or nephrotoxicity within the concentration range used in our experiments, consistent with previous reports [59,60,61]

In trained monocytes, elevated NAD + /NADH ratios and lactate accumulation modulate HDAC activity and influence downstream gene expression (167, 168)

10.1097/INF.0000000000003146 53

WangCLiuXRenZDuXLiNSongXet al

A OneStoneTwoBirds strategy for intervertebral disc repair: constructing a reductive chelation hydrogel to mitigate oxidative stress and promote disc matrix reconstruction

Targeting the NLRP3 inflammasome in psoriasis