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ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

It is noteworthy that the peculiar perturbation we generated in the HPV-16 E7 mutant molecule by amino acid substitutions in the CR3 region did not appreciably affect binding with pRb, which interacts with HPV-16 E7 mostly via the CR2 region, though involvement of the C-terminal region has been reported [9], [35]

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10.1016/j.ajpath.2014.09.016 119