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Additionally, clinical samples should be employed to validate the correlation between serum CAT levels and markers of ferroptosis in articular cartilage (e.g., GPX4 activity) as well as disease severity in OA patients

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UA is considered the major circulating antioxidant and thus provides protection from oxidative stress and consequent damage

Since dimercaprol also readily chelates copper, it is used in the treatment of Wilsons disease, a hereditary disease in which excess copper is accumulated in the body (Leggio et al., 2005)

in 2021 [17], focusing on epidemiological studies, revealed that increased mushroom consumption was associated with a lower incidence of cancer in Asian cultures

doi: 10.1146/annurev-pharmtox-010818021856 89 PiotrowskaMSwierczynskiMFichnaJPiechota-PolanczykA