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Neuropsychopharmacology 39 , 477487 (2013)

10.1007/s00018-014-1670-8 53 Figueroa-MndezR.Rivas-ArancibiaS

Sirtuins can only work when enough NAD+ is present, so falling NAD+ levels mean weaker control over processes tied to aging and recovery

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These findings were supported by electrophysiological assays using Ussing chambers that demonstrated viniferins potent ability to inhibit ATP-stimulated Cl secretion across the colonic epithelium, suggesting a pharmacologically relevant suppression of CaCC-mediated ion transport