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doi: 10.3389/fphar.2025.1615681 Received 23 May 2025 Accepted 14 July 2025 Published 24 July 2025 Volume 16 - 2025 Edited by Eoin Daniel OSullivan, Royal Brisbane and Womens Hospital, Australia Reviewed by Prerna Kumar, Tulane University, United States David Baird, University of Edinburgh, United Kingdom Sumaya Akter, Noakhali Science and Technology University, Bangladesh Saswat Kumar Mohanty, Brown University, United States Updates Copyright 2025 Zhang, Ni, Lin, Wang, He, Yuan, Han and Zuo

doi: 10.1016/j.neuropharm.2017.01.025 12

Alterations in systemic metabolic and inflammatory states can promote endothelial cell dysfunction, reducing the integrity of the BBB and potentially allowing peripheral blood factors to leak into the CNS compartment

Three T3SSs (T3SS-1, T3SS-2, and T3SS-3) are encoded in the B

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Understanding the pathological process of myocardial and neural cell injury is key to developing protective strategies for CCVDs