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It is likely for such treatment including IVIG and corticosteroids that the time window to initiation to achieve a beneficial effect is very short to be feasible in clinical practice

In support of the NRF2 pathway being a potential target for the treatment of ALS, studies have shown that NRF2 overexpression in astrocytes provided neuroprotection against mutated SOD1-induced toxicity and increased the median survival of mutant SOD1 transgenic mice (Vargas et al., 2008

Although current studies largely ignore the interplay between SHBG, androgens and oestrogens and focus instead on their individual actions, some of these findings remain valuable

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doi: 10.1097/MED.0b013e32833363cc 185 Rog-ZielinskaEAThomsonAKenyonCJBrownsteinDGMoranCMSzumskaDet al