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Research indicates Dihexa treatment can improve functional outcomes in animal models of cognitive impairment, with behavioral improvements correlating with structural brain changes including increased synaptic density and improved neural connectivity patterns

To evaluate the functional significance of these spine changes Nlel-AnglV and Dihexa stimulated hippocampal neurons were immunostained against the glutamatergic presynaptic marker VGLUT1 (Balschun, Moechars et al

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n = 25) between the postsynaptic marker PSD-95 and the postsynaptic spines suggest that the newly formed spines have a functional postsynaptic element

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This may give some readers pause if theyre familiar with lithium as used for psychiatric disorders, namely major depression and bipolar disorder