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Multivariate analysis revealed some predictive factors of 90 th -day poor clinical outcomes, including older age (OR 1.12, p = 0.007), male sex (OR 14.56, p = 0.023), predominant hemisphere lesion (OR12.30, p = 0.026), increased NIHSS of 2 points (OR 34.47, p = 0.006), and large artery atherosclerosis classification (OR 13.08, p = 0.016)

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Next-Generation Signal Peptides The broader signal-peptide field is expanding toward designed analogs, PEGylated derivatives, and copper-coordinating analogs of GHK that may modify pharmacokinetics or stability

144 These NPs modulated inflammatory pathways, enhanced neutrophil efferocytosis, and promoted anti-inflammatory macrophage phenotypes