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Niacin (100 mg/day in dogs) may also lower hypertriglyceridemia by decreasing the production of VLDL and the release of fatty acids from adipocytes (113, 114) ( Table 2 )

Experiments that knocking down hepatic FMO3 in LDL receptor-deficient mice demonstrate that FMO3 knockdown can alter bile secretion, intestinal absorption, and constrains hepatic oxysterol and cholesterol ester production in cholesterol-fed mice (Shih et al., 2015