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Similarly, vitamin D supplementation, although safe at recommended doses, can lead to hypercalcemia and hypercalciuria if administered in excess [151]

The synergy emerges because MOTS-c increases demand for NAD+-dependent processes while 5-Amino-1MQ increases NAD+ supply

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For example, in a study by Liu et al., a novel dual receptor recognizing the cell-penetrating peptide R8-dGR, which could bind to both integrin v 3 and neuropilin-I receptors, was used to functionalize liposomes [154]