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During a three-week treatment period, both Cagrilintide and salmon calcitonin (sCT), another amylin receptor agonist, produced an acute reduction in food intake in WT mice on day 1 by 53% and 42%, respectively, but not in RAMP1/3 KO mice

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Dihexa binds to HGF with extraordinary affinity (Figure 43), blocking HGF dimerization (Figure 44), and markedly augments the ability of HGF to signal to c-Met ( Figure 45) and initiate cellular responses (as discussed above)