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[] In contrast to ApoJ, ectodysplasin A (Eda) disturbs insulin signaling, the expression of Eda in the liver is controlled by PPAR and RXR-, its levels are increased in circulation under conditions of obesity, then, they arrive to the skeletal muscle, and promote JNK activation and inhibitory serine phosphorylation of IRS1, and thus, contribute to obesity-induced insulin resistance of the skeletal muscle

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(PubMed) Henkin RI, Patten BM, Re PK, Bronzert DA

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Appl Spectrosc Rev 53:313332