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GSH homeostasis and GST expression in non-mammalian phyla can also influence proliferative signaling pathways

The application of the in vivo model showed that Tim-AIII inhibited the progression of subcutaneous xenograft tumors and lung metastases tumors without apparent toxicity

Cox regression model confirmed the prognostic impact of IGF-1 in BLCA ( p = 4.4e0.6), CHOL ( p = 3.8e0.2), LAML ( p = 7.8e0.3), and SARC ( p = 4.2e0.2) with the same trend ( Figure 2E )

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In contrast, zinc mis-metalation alters SOD1 folding and indirectly affects its catalytic activities (214) ( Figure 2C )

In addition, NRF2 is regulated by the cytoplasmic inhibitor Kelch-like ECH-associating protein 1 (KEAP1)