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Methods: Literature survey was done using key words such as heavy metals, oxidative stress and kidney damage using search engines for free scientific publications such as PubMed database, FreeFullPDF.com and Google Scheler

Circulating -HB is converted to acetyl-CoA via the ketosis pathway in the muscles, heart, and brain, and this intermediate is then further used to generate adenosine triphosphate (ATP) via the citric acid cycle 12

Milk thistle is widely recognised for its liver-supportive properties, largely due to its active compound silymarin, a group of flavonoids with antioxidant and anti-inflammatory effects