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Combining elesclomol with the SIRT2 inhibitor AGK2 synergistically induced cuproptosis in GC cells and suppressed tumor growth in mice, suggesting that targeting both copper delivery and METTL16 lactylation could be a potential therapeutic strategy

doi: 10.1101/2023.04.12.536655 139 ValenteE

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And human reports described onset around an hour with duration up to 20 hours an effect decoupled from drug presence

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