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3.3 Quality of evidence PRISMA 2020

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This review begins by discussing the discovery of the BBB and its physiological functions, and then provides a detailed description and illustration of its microstructure

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Further investigation is required to elucidate factors such as absorption rate, pharmacokinetics, metabolite characterization, and the physiological effects of these metabolites to establish a correlation between the SAR of flavonoids and their impact on human nutrition and medicine

Melatonin shifts human orcadian rhythms according to a phase-response curve