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However, excessive vascularization during the mid-phase of wound healing impedes fibroblast growth and wound tissue re-epithelialization 74

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Development of cyclodextrin microspheres for pulmonary drug delivery

In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

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For a broader explanation of how this gap is evaluated across peptide categories, see Peptide Research vs Human Use and Peptide Side Effects