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In Parkinsons disease (PD) models, exercise increases the density of dendritic spines in medium spiny neurons (MSNs) in the striatum, thereby improving motor dysfunction (Palasz et al., 2019)

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Biological Targets for Weight-Loss Drug Development Anti-obesity drugs target either central nervous system pathways that regulate sensations of satiety and fullness, or peripheral modulators of digestion, metabolism and lipogenesis (Figure 2)

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Given the pharmacological limitations of existing PHGDH inhibitors, such as poor aqueous solubility and insufficient target specificity, nano-delivery systems have significantly improved tumor accumulation and therapeutic index through passive and active targeting strategies

87 In fact, different exercise type, intensity, and duration can either increase or decrease the uptake and utilization of glucose