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If none of the above has failed along the way, B12 has reached its first destination safe and sound

As deficiency deepens, neurological symptoms can appear: tingling or numbness in the hands and feet, balance problems, a sore or "beefy" red tongue, memory changes, and mood shifts

[9, 11] Inadequate dietary intake, especially in vegetarians and vegans, leads to a deficiency in vitamin B12

Unexplained anemia: Particularly in a specific form (megaloblastic anemia) where the red blood cells are enlarged, a vitamin B12 deficiency is a common cause

al published the first Gene Review of Disorders of Intracellular Cobalamin Metabolism