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[46] [48] Pathophysiology [edit] Although the healthy body stores three to five years' worth of B 12 in the liver, the usually undetected autoimmune activity in one's gut over a prolonged period of time leads to B 12 depletion and the resulting anemia

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So, the placebo was saline control

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All patients were started on a standard diet (30 kcal/kg/day, consisting of 5060% carbohydrate, 2030% fat, and 1520% protein) and received exercise counseling beginning 3 months before glutathione treatment