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The Keap1-Nrf2-ARE pathway as a potential preventive and therapeutic target: an update

Proc Natl Acad Sci USA (2010) 107:745560

According to these findings, loss of GNMT impairs nucleotide biosynthesis, whereas GNMT overexpression enhances nucleotide biosynthesis and improves DNA integrity by reducing uracil misincorporation in DNA both in vitro and in vivo [1]