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The IRE1 pathway activates JNK signaling, promoting inflammatory cytokine production and exacerbating insulin resistance (Su et al., 2013)

In the context of existing neuroinflammatory disease, infection, organ injury/failure, and/or systemic inflammation, can perpetuate further cerebral vascular and CNS injury

Patients report feeling more energetic and less hungry, making it easier to adhere to a healthier lifestyle

Understanding this process helps explain why rest, hydration and sensible dietary choices can support recovery

Gene 511, 218223 (2012)

Moreover, anti-inflammatory action of this plant could be due to the presence of triterpenes oleanolic, asiatic, and maslinic acids (42)