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5.4 Regulation of mitochondrial dysfunction Mitochondria, as subcellular organelles containing DNA, provide energy to cells through oxidative phosphorylation (Antolnez-Fernndez et al., 2024) and are implicated in various pathophysiological processes in VaD

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Existing preclinical studies in animal models have shown promising results with ferroptosis inhibitors, iron chelation, and microbiota-based therapies such as probiotics, dietary interventions, and fecal microbiota transplantation (FMT)

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Studies show oral glutathione has only 20% bioavailability

However, human clinical studies have generally used doses ranging from 250900 mg per day