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The variation in the erythrocyte GSH system without nuclear capacity to restore homeostasis may be an early biomarker of chronic oxidative stress that could be a first step in the development of cardiometabolic complications

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doi:10.1530/EJE-12-0555 [DOI] [PubMed] [Google Scholar] 18.Ziegler D, Ametov A, Barinov A, et al

On the other hand, mechanistic experiments demonstrated that compound 67 promoted (i) an alteration in the energetic metabolism with a significant loss of ATP that is associated with the depolarization of mitochondrial potential ( m ), (ii) a decrease of intracellular ATP levels with an alteration of plasma membrane permeability, and (iii) a significant ROS production, which is the typical mode of action found for 4-aminoquinolines

An example is fexofenadine (Allegra), an antihistamine used to relieve allergy symptoms that is available by prescription and over the counter