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Crohns disease Since aspirin increases the risk of Crohns disease (but not ulcerative colitis), people with Crohns disease should consider avoiding the medication (Chan 2011)

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Pangrazzi L, Balasco L, Bozzi Y

The underlying mechanisms associated were the inhibition of ERK1/2 MAPK phosphorylation and the DNA binding activity of NF-B [177]