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After initial dialysis, multi histidine-tagged receptor proteins were purified with immobilized metal affinity column chromatography and the peak fractions were followed by size exclusion column chromatography as previously described [23]

In conclusion, our structural and functional analyses provide a large body of novel information for defining the molecular mechanism underlying the activation of c-MET in response to HGF and NK1 and paves the way for the eventual therapeutic intervention of diseases caused by aberrant activation of c-MET

The results of a sequential supplementation trial in 53 men and women indicated that after optimization of folate status with folic acid supplements, vitamin B 12 became the major determinant of plasma homocysteine levels (30)

therefore, vitamin D supplementation in an IMID combined test could further improve the therapeutic effect of anti-CD38 antibodies ( CD38 mRNA levels in MM cells and the amount of CD38 on the cell surface