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The ATTAIN-MAINTAIN Phase 3 trial specifically evaluated this scenario, testing whether patients who had achieved weight loss with injectable GLP-1 receptor agonists (semaglutide or tirzepatide) could switch to oral orforglipron while maintaining their weight loss

Ciclosporin for ASUC treatment has been superseded by infliximab

A phase 2 randomised controlled trial published in the New England Journal of Medicine (2023) reported substantial weight loss and improvements in glycaemic parameters, though the trial was conducted in a closely monitored clinical setting with defined eligibility criteria

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doi: 10.1016/j.toxlet.2015.11.010, 104

CJC-1295 with DAC offers easier dosing in research models