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Neuroactive peptides work through mechanisms such as brain-derived neurotrophic factor (BDNF) upregulation, HGF/c-Met signaling, and modulation of monoamine neurotransmitters (Table 4)

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Small molecule GRK inhibitors, including paroxetine, Takeda compound 101, and CCG224063, attenuate GRK2-mediated desensitization of vasoconstrictor-induced arterial contractions, highlighting a potential strategy for blood pressure regulation by targeting GRK2 function [157]

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