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This provides an explanation for the involvement of neurexins proteins in the mechanism of sustained antidepressant effect mediated by BDNF signaling, but recent studies have not clarified their relative upstream and downstream relationship to BDNF signaling, and the mechanism of this regulation at the protein level awaits further clarification

G.GrundmanM.ZagoW.et al

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And when those regulatory roles go wrong, thats oxidative stress

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