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Subsequent principal component analysis and differential expression analysis were carried out with edgeR and scikit-learn (version 1.0.2)

In terms of pathogenicity, distinct strains show obvious divergence in core virulence traits: for example, chromosome 7 trisomic strains present attenuated hyphal formation due to NRG1 overexpression, while euploid strains form robust hyphae with stronger tissue adhesion and invasion capabilities (Kakade et al., 2023)

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10.1016/j.bbi.2016.12.024 87