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Doxorubicin reduced glutamate clearance, as showed by a decline in the rate of uptake of glutamate in the frontal cortex of mice ( In addition, doxorubicin injection distinctly reduced the levels of two monoamines that are closely related to cognitive function: serotonin (5-HT) and dopamine (DA) ( Changes in the levels of neurotransmitters lead to abnormalities in the transduction of nerve signals, leading to cognitive impairment

Cluster three (blue) emphasizes PSCI risk factors, including keywords such as dementia, Alzheimer's disease, risk factor, vascular dementia, TIA (transient ischemic attack), brain infarction, MRI, small vessel disease, vascular cognitive impairment, and age. The smallest cluster (yellow) primarily relates to assessment and diagnosis, covering terms such as MMSE, MoCA (Montreal Cognitive Assessment), validity, diagnosis, frequency, reliability, validation, neurological disorders, neuropsychology, and questionnaire. To explore the research topics that have captured attention from 2010 to early 2023, we used CiteSpace in conjunction with the alluvial generator to successfully plot the alluvial flow graph of PSCI's academic keywords (Figure 8C)

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The peptide's potential to mimic BDNF-like activity underscores its therapeutic interest in neurodegenerative diseases and cognitive disorders

Recent advances have explored PEGylated lipid nanoparticles, which combine the benefits of stealth properties (to evade immune clearance) and controlled delivery

BPC-157 BPC-157 was the most frequently represented peptide agent in musculoskeletal research