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Indeed, the liver has been reported to need a maximal synthesis of GSH for detoxifying exogenous xenobiotics, such as acetaminophen 75,76

70 Glutathione Side Effects and Risks Glutathione injections are generally considered safe, but side effects can occurespecially at higher doses

The development of innovative delivery systems, particularly inhaled nanotherapeutics and targeted exosomes, offers promising solutions to the critical challenge of cell-type specificity, potentially enabling precise targeting of alveolar macrophages and epithelial cells while minimizing systemic effects

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This indicates that although the C28-C31 pair may participate in the reduction of GSSG, its involvement is not evident in the transient state kinetic observations we report

Unlike the SmTGR U597C variant for which the flavin is observed to begin reoxidizing at 0.1 s in the presence of limiting NADPH concentration (Smith et al., 2023), this variant maintains the partially reduced flavin and thiolate-FAD charge transfer state