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10.1016/j.crmeth.2022.100280 125 KirkbyN

Metformin, a first-line therapy, has been shown in preclinical models to activate AMPK, improve mitochondrial function, and alleviate oxidative stress, thereby conferring resistance to ferroptosis in various cell types (95)

10.1161/ATVBAHA.110.210500 180 OuZ.WangY.YaoJ.ChenL.MiaoH.HanY.et al (2023)

It is also not recommended for pregnant or breastfeeding women or individuals under 18

This leads to one of two outcomes: programmed cell death (apoptosis) or a state of irreversible growth arrest known as cellular senescence

however, in PD patients, it becomes persistent and leads to the accumulation of activated myofibroblasts that alters the healthy structure and function of the peritoneal membrane, thus hindering the effective treatment (Strippoli et al., 2020