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This system is tasked with balance or "homeostasis"

Oral delivery of melatonin results in extremely low dosages absorbed as a result of low oral bioavailability, GI and liver metabolism of the compound, and lack of systemic circulation of therapeutic dosages

indeed, the genetic disruption of host oxidases [28], or the oral administration of antioxidants [29], significantly reduces gastric inflammation [29], colonization [30], and/or tumor formation [31] in rodent models of infection

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Mikrochim Acta 191 , 59 (2023)