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The Effect of Salicylates (A) on the estimation of thiamine by the thiochrome method, (B) on the excretion of thiamine

To test this, we bred the MMTV-PyMT transgenic mouse strain (which spontaneously develops breast tumors) 47 with an inducible whole-body knockout mouse strain for the rate-limiting step in GSH synthesis, glutamate-cysteine ligase catalytic subunit (GCLC) (Rosa26-CreERT2 Gclc f/f ) 48,49