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The number of patients with an increase in intraocular pressure of more than 10 mmHg from baseline anytime during the study was 12% for 350 g, 17% for 700 g, and 3% for the untreated controls.117 Kawaji et al.122 evaluated in 20 patients the effectiveness and safety of trans-tenon retrobulbar injection of 40 mg of TA for ME associated with BRVO after vitrectomy

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[8]Current Patent Assignee: COLORADO STATE UNIVERSITY - US10266408, 2019, B2 Location in patent: Page/Page column 28

Its use with irinotecan resulted in moderate toxicities and insufficient clinical effectiveness ( Pazopanib, approved for sarcoma, is also a multikinase inhibitor targeting VEGFR and PDGFR

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