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Cancer cells exhibit high mutability due to internal mechanisms, like the accumulation of spontaneous mutations, as well as external influences, including environmental exposures and radiation [88]

It is therefore important to cancerparticularly lung, ovarian, and breast combine proteins that complement one an- cancerby up to 50%.43 other so that a complete set of amino acids is provided

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Even highly soluble formulations remain susceptible to rapid systemic clearance and nonspecific tissue distribution, which can diminish tumor accumulation and increase offtarget toxicity